Pleiotropic Mutations Are Subject to Strong Stabilizing Selection

Pleiotropic mutations are subject to strong stabilizing selection.

The assumption that pleiotropic mutations are more deleterious than mutations with more restricted phenotypic effects is an important premise in models of evolution. However, empirical evidence supporting this assumption is limited. Here, we estimated the strength of stabilizing selection on mutations affecting gene expression in male Drosophila serrata. We estimated the mutational variance (VM...

Pleiotropic mutations are subject to strong stabilizing selection 1 2 3

Social calls are subject to stabilizing selection in insular bats

Laboratorio di Ecologia Applicata, Dipartimento Ar.Bo.Pa.Ve., Facoltà di Agraria, Università degli Studi di Napoli Federico II, Portici (Napoli), Italy, School of Biological Sciences, University of Bristol, Bristol, UK, Department of Biology, University of Madeira, Campus da Penteada, Funchal, Portugal, Forestry and Conservation, Via Botticelli, Cassino (Frosinone), Italy and Faculty of Science...

Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.

We show that in polymorphic populations many polygenic traits pleiotropically related to fitness are expected to be under apparent "stabilizing selection" independently of the real selection acting on the population. This occurs, for example, if the genetic system is at a stable polymorphic equilibrium determined by selection and the nonadditive contributions of the loci to the trait value eith...

Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters.

We demonstrate that, in a model incorporating weak Gaussian stabilizing selection on n additively determined characters, at most n loci are polymorphic at a stable equilibrium. The number of characters is defined to be the number of independent components in the Gaussian selection scheme. We also assume linkage equilibrium, and that either the number of loci is large enough that the phenotypic ...